| Cat # | Size | Price | Quantity | |
|---|---|---|---|---|
| 201401 | 100 ug | $35 | ||
| 201402 | 500 ug | $70 |
| Clone | GK1.5 |
|---|---|
| Application | FC |
| Reactivity | Mouse |
| Format | Purified |
| Target Name | CD4, T4, Leu3a |
| Isotype | Rat IgG2b |
| Antibody Type | Monoclonal |
| Regulatory Status | RUO |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide |
| Protein Concentration | 0.5 mg/mL |
| Storage and Handling | The antibody solution should be stored between 2°C and 8°C |
| Recommended Usage | For flow cytometric staining, it is recommended to use less than 0.2 ug of this reagent per 0.5-1.0 million cells in a 100 µL volume. Optimal reagent performance should be determined by titration for each specific application |
CD4 is a 55 kDa type I transmembrane glycoprotein and a member of the immunoglobulin superfamily. It acts as a co-receptor that, in cooperation with the T cell receptor (TCR), binds to MHC class II molecules on antigen-presenting cells (APCs), stabilizing the immunological synapse and enhancing TCR signaling through association with the Src-family kinase Lck. CD4 is expressed by most thymocytes, the majority of helper T cells, a subset of NK-T cells, and weakly by dendritic cells and macrophages. During thymic development, CD4 is co-expressed with CD8 on double-positive thymocytes before lineage commitment to CD4⁺ or CD8⁺ single-positive T cells. CD4 plays a critical role in T cell development and is essential for optimal function of mature T cells.
