| Cat # | Size | Price | Quantity | |
|---|---|---|---|---|
| 805701 | 25 ug | $145 | ||
| 805702 | 100 ug | $295 |
| Application | ELISA, BLI |
|---|---|
| Format | Liquid, Purified |
| Expression Host | CHO |
| Target Name | TROP2,TACSTD2, GA733-1, M1S1 |
| Species | Human |
| Sources | Recombinant Human Trop2 (Gln31-Thr274) with C-terminus His-Avi tag is expressed in CHO cell. |
| Accession Number | P09758 |
| Molecular Weight | The protein has a predicted molecular weight of 31 kDa. Under DTT-reducing conditions, it migrates at approximately 35-45 kDa on SDS-PAGE. |
| Affinity Tag | C-His-Avi |
| Purity | >95% based on SDS-PAGE under reducing condition |
| Regulatory Status | RUO |
| Formulation | 1xPBS buffer, pH7.4, 0.22 µm filtered |
| Endotoxin level | Not tested |
| Protein Concentration | 25µg size is bottled at 0.2mg/mL concentration. 100 µg size is supplied at a lot-specific concentration. |
| Storage and Handling | Briefly centrifuge the vial upon receipt. An unopened vial can be stored at 4°C for up to 2 weeks, or at -20°C or below for up to six months. The protein may be further diluted to 0.1 mg/mL using 0.22 µm-filtered PBS buffer (pH 7.4). For long-term storage, the diluted stock solution should be aliquoted and stored at ≤ –70°C to minimize freeze-thaw cycles. If additional dilution is required, carrier proteins such as FBS or BSA should be added to maintain protein stability. |
TROP-2, also known as TACSTD2, is a 35.7 kD protein that belongs to the EpCAM family. It is a cell surface receptor that can transduce calcium signals. Mutations of this gene are associated with gelatinous drop-like corneal dystrophy. TROP-2 is highly expressed in a variety of epithelial cancers, making it a potential therapeutic target. The cytoplasmic tail of TROP-2 contains potential phosphorylation sites and a phosphatidyl-inositol binding sequence, suggesting its role in signal transduction. As a member of a family of at least two type I membrane proteins, TROP-2 is closely related to EpCAM, also known as TROP-1, and may play a role in regulating carcinoma cell growth.
