| Cat # | Size | Price | Quantity | |
|---|---|---|---|---|
| 805501 | 25 ug | $145 | ||
| 805502 | 100 ug | $295 |
| Application | ELISA, BLI |
|---|---|
| Format | Liquid, Purified |
| Expression Host | CHO |
| Target Name | CD7, GP40, TP41, LEU-9, Tp40 |
| Species | Human |
| Sources | Recombinant Human CD7 (Ala26-Pro180) with C-terminus His tag is expressed in CHO cell |
| Accession Number | P09564 |
| Molecular Weight | The protein has a predicted molecular weight of 16 kDa. Under DTT-reducing conditions, it migrates at approximately 30-40 kDa on SDS-PAGE. |
| Affinity Tag | C-His |
| Purity | >95% based on SDS-PAGE under reducing condition |
| Regulatory Status | RUO |
| Formulation | 1xPBS buffer, pH7.4, 0.22 µm filtered |
| Endotoxin level | Not tested |
| Protein Concentration | 25µg size is bottled at 0.2mg/mL concentration. 100 µg size is supplied at a lot-specific concentration. |
| Storage and Handling | Briefly centrifuge the vial upon receipt. An unopened vial can be stored at 4°C for up to 2 weeks, or at -20°C or below for up to six months. The protein may be further diluted to 0.1 mg/mL using 0.22 µm-filtered PBS buffer (pH 7.4). For long-term storage, the diluted stock solution should be aliquoted and stored at ≤ –70°C to minimize freeze-thaw cycles. If additional dilution is required, carrier proteins such as FBS or BSA should be added to maintain protein stability. |
CD7, also known as GP40, LEU-9, and TP41, is a 40 kD transmembrane glycoprotein of the immunoglobulin superfamily. It is expressed on thymocytes, T cells, NK cells, myeloid precursor cells, and some leukemia cells. CD7 plays a key role in T cell interactions and early lymphoid development. It activates the PI3K pathway through its intracellular YEEM motif and induces mitogenesis and IL-2 production when treated with anti-CD3 or PMA. CD7 is overexpressed in classical Hodgkin lymphoma and T-cell acute lymphoblastic leukemia (T-ALL), and is a target for CAR T-cell therapies.
