Andes Virus Glycoprotein Gn Head/Gc Complex (C-His)

Cat #	Size	Price	Quantity
607101	25 μg	$500
607102	100 μg	$1350

Bulk/Custom

Product Details

Application	ELISA, BLI
Format	Liquid, Purified
Expression Host	CHO
Target Name	Andes virus glycoprotein Gn/Gc complex, Andes virus Gn/Gc complex, ANDV glycoprotein complex, Andes orthohantavirus envelope glycoprotein complex, Hantavirus Gn/Gc complex, Andes virus Gn head and Gc glycoprotein complex
Species	Andes Virus
accession number	AF291703.2
Sources	Recombinant Andes Virus Glycoprotein Gn Head (Met19–Glu374)/Gc (Glu652-Asn1107) complex with a C-terminal histidine tag is expressed in CHO cells. The protein is derived from the Andes virus strain Chile-9717869.
Molecular Weight	This protein has a predicted molecular weight of 90–95 kDa (without glycosylation).
Affinity Tag	C-His
Purity	>95% based on SDS-PAGE under reducing condition
Regulatory Status	RUO
Formulation	1xPBS buffer, pH7.4, 0.22 µm filtered
Endotoxin level	Not tested
Protein Concentration	25µg size is bottled at 0.2mg/mL concentration. 100 µg size is supplied at a lot-specific concentration.
Storage and Handling	Briefly centrifuge the vial upon receipt. An unopened vial can be stored at 4°C for up to 2 weeks, or at -20°C or below for up to six months. The protein may be further diluted to 0.1 mg/mL using 0.22 µm-filtered PBS buffer (pH 7.4). For long-term storage, the diluted stock solution should be aliquoted and stored at ≤ –70°C to minimize freeze-thaw cycles. If additional dilution is required, carrier proteins such as FBS or BSA should be added to maintain protein stability.

Background Information

Andes virus (ANDV) is an enveloped negative-sense RNA virus belonging to the genus Orthohantavirus within the family Hantaviridae. Andes virus is one of the primary causative agents of hantavirus cardiopulmonary syndrome (HCPS) in South America and is unique among hantaviruses for its documented capability of human-to-human transmission.
The Andes virus glycoprotein precursor (GPC) is proteolytically cleaved into two envelope glycoproteins, Gn and Gc, which assemble into heteromeric spike complexes on the virion surface. The Gn head domain primarily mediates receptor attachment and immune recognition, whereas the Gc glycoprotein functions as a class II fusion protein responsible for membrane fusion during viral entry. The Gn/Gc complex represents a major target for neutralizing antibodies and vaccine development. Recombinant Andes Virus Glycoprotein Gn Head/Gc Complex is widely used in studies of viral entry, structural biology, antibody discovery, epitope mapping, serological assay development, and antiviral therapeutic research.

Learn more about Andes Virus in our detailed Infographic.

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